Functional significance of UDP-glucuronosyltransferase (UGT) variants in the metabolism of active tamoxifen metabolites

Tamoxifen (TAM) is a selective estrogen receptor modulator widely used in the prevention and treatment of breast cancer. A major mode of metabolism of the major active metabolites of TAM, 4-OH-TAM and endoxifen, is by glucuronidation via the UDP-glucuronosyltransferase (UGT) family of enzymes. To ex...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Blevins-Primeau, Andrea S., Sun, Dongxiao, Chen, Gang, Sharma, Arun K., Gallagher, Carla J., Amin, Shantu, Lazarus, Philip
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2009
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2683344/
https://ncbi.nlm.nih.gov/pubmed/19244109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-3708
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