Decoding the Cryptic Active Conformation of a Protein by Synthetic Photoscanning: INSULIN INSERTS A DETACHABLE ARM BETWEEN RECEPTOR DOMAINS

Proteins evolve in a fitness landscape encompassing a complex network of biological constraints. Because of the interrelation of folding, function, and regulation, the ground-state structure of a protein may be inactive. A model is provided by insulin, a vertebrate hormone central to the control of...

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Detalhes bibliográficos
Main Authors: Xu, Bin, Huang, Kun, Chu, Ying-Chi, Hu, Shi-Quan, Nakagawa, Satoe, Wang, Shuhua, Wang, Run-Ying, Whittaker, Jonathan, Katsoyannis, Panayotis G., Weiss, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2682907/
https://ncbi.nlm.nih.gov/pubmed/19321435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M900087200
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