Engineered Human Antibody Constant Domains with Increased Stability

The immunoglobulin (Ig) constant CH2 domain is critical for antibody effector functions. Isolated CH2 domains are promising as scaffolds for construction of libraries containing diverse binders that could also confer some effector functions. However, previous work has shown that an isolated murine C...

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Detalhes bibliográficos
Main Authors: Gong, Rui, Vu, Bang K., Feng, Yang, Prieto, DaRue A., Dyba, Marzena A., Walsh, Joseph D., Prabakaran, Ponraj, Veenstra, Timothy D., Tarasov, Sergey G., Ishima, Rieko, Dimitrov, Dimiter S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2682868/
https://ncbi.nlm.nih.gov/pubmed/19307178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M900769200
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