MDM2 Acts Downstream of p53 as an E3 Ligase to Promote FOXO Ubiquitination and Degradation

Members of the FOXO (forkhead O) class of transcription factors are tumor suppressors that also control aging and organismal life span. Mammalian FOXO degradation is proteasome-mediated, although the ubiquitin E3 ligase for FOXO factors remains to be defined. We show that MDM2 binds to FOXO1 and FOX...

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Main Authors: Fu, Wei, Ma, Qiuping, Chen, Lei, Li, Pengfei, Zhang, Mu, Ramamoorthy, Sivapriya, Nawaz, Zafar, Shimojima, Tsukasa, Wang, Hengbin, Yang, Yonghua, Shen, Zheng, Zhang, Yingtao, Zhang, Xiaohong, Nicosia, Santo V., Zhang, Yanping, Pledger, Jack W., Chen, Jiandong, Bai, Wenlong
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Mechanisms of Signal Transduction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2682847/
https://ncbi.nlm.nih.gov/pubmed/19321440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M901758200
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