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SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress
SIRT1 is the closest mammalian homologue of yeast SIR2, an important ageing regulator that prolongs lifespan in response to caloric restriction. Despite its importance, the mechanisms that regulate SIRT1 activity are unclear. Our study identifies a novel post-translational modification of SIRT1, nam...
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| Главные авторы: | , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2007
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3201724/ https://ncbi.nlm.nih.gov/pubmed/17934453 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb1645 |
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