Reduced-Function SLC22A1 Polymorphisms Encoding Organic Cation Transporter 1 and Glycemic Response to Metformin: A GoDARTS Study

OBJECTIVE: Metformin is actively transported into the liver by the organic cation transporter (OCT)1 (encoded by SLC22A1). In 12 normoglycemic individuals, reduced-function variants in SLC22A1 were shown to decrease the ability of metformin to reduce glucose excursion in response to oral glucose. We...

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Main Authors: Zhou, Kaixin, Donnelly, Louise A., Kimber, Charlotte H., Donnan, Peter T., Doney, Alex S.F., Leese, Graham, Hattersley, Andrew T., McCarthy, Mark I., Morris, Andrew D., Palmer, Colin N.A., Pearson, Ewan R.
Formato: Artigo
Idioma:Inglês
Publicado: American Diabetes Association 2009
Assuntos:
Genetics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2682689/
https://ncbi.nlm.nih.gov/pubmed/19336679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-0896
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