TRAF6 Establishes Innate Immune Responses by Activating NF-κB and IRF7 upon Sensing Cytosolic Viral RNA and DNA

BACKGROUND: In response to viral infection, the innate immune system recognizes viral nucleic acids and then induces production of proinflammatory cytokines and type I interferons (IFNs). Toll-like receptor 7 (TLR7) and TLR9 detect viral RNA and DNA, respectively, in endosomal compartments, leading...

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Detalhes bibliográficos
Main Authors: Konno, Hiroyasu, Yamamoto, Takuya, Yamazaki, Kohsuke, Gohda, Jin, Akiyama, Taishin, Semba, Kentaro, Goto, Hideo, Kato, Atsushi, Yujiri, Toshiaki, Imai, Takahiko, Kawaguchi, Yasushi, Su, Bing, Takeuchi, Osamu, Akira, Shizuo, Tsunetsugu-Yokota, Yasuko, Inoue, Jun-ichiro
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2682567/
https://ncbi.nlm.nih.gov/pubmed/19479062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005674
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