EVIDENCE FOR BIDENTATE SUBSTRATE BINDING AS THE BASIS FOR THE K48 LINKAGE SPECIFICITY OF OTUBAIN 1

Otubain 1 belongs to the ovarian tumor (OTU) domain class of cysteine protease deubiquitinating enzymes. We show here that human otubain 1 (hOtu1) is highly linkage-specific, cleaving Lys48 (K48)-linked polyubiquitin but not K63-, K29-, K6-, or K11-linked polyubiquitin, or linear α-linked polyubiqui...

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Detalhes bibliográficos
Main Authors: Wang, Tao, Yin, Luming, Cooper, Eric M., Lai, Ming-Yih, Dickey, Seth, Pickart, Cecile M., Fushman, David, Wilkinson, Keith D., Cohen, Robert E., Wolberger, Cynthia
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2682458/
https://ncbi.nlm.nih.gov/pubmed/19211026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.12.085
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