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U2504 Determines the Species Specificity of the A-site Cleft Antibiotics. The Structures of Tiamulin, Homoharringtonine and Bruceantin Bound to the Ribosome

Structures have been obtained for the complexes tiamulin, homoharringtonine and bruceatin form with the large ribosomal subunit of Haloarcula marismortui at resolutions ranging from 2.8 to 3.2 Å. They show that these inhibitors all block protein synthesis by competing with the amino acid side chains...

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Detalhes bibliográficos
Main Authors: Gürel, Güliz, Blaha, Gregor, Moore, Peter B., Steitz, Thomas A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2682339/
https://ncbi.nlm.nih.gov/pubmed/19362093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.04.005
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