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Mutations Outside the Anisomycin Binding Site Can Make Ribosomes Drug-Resistant

Eleven mutations have been identified in 23S rRNA that make Haloarcula marismortui resistant to anisomycin, an antibiotic that competes with the amino acid side chains of aminoacyl tRNAs for binding to the A-site cleft of the large ribosomal unit. The correlation observed between the sensitivity of...

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Autors principals: Blaha, Gregor, Gurel, Guliz, Schroeder, Susan J., Moore, Peter B., Steitz, Thomas A.
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2442718/
https://ncbi.nlm.nih.gov/pubmed/18455733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.03.075
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