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Mutations Outside the Anisomycin Binding Site Can Make Ribosomes Drug-Resistant
Eleven mutations have been identified in 23S rRNA that make Haloarcula marismortui resistant to anisomycin, an antibiotic that competes with the amino acid side chains of aminoacyl tRNAs for binding to the A-site cleft of the large ribosomal unit. The correlation observed between the sensitivity of...
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| Asıl Yazarlar: | , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2008
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2442718/ https://ncbi.nlm.nih.gov/pubmed/18455733 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.03.075 |
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