Farnesoid X Receptor Deficiency in Mice Leads to Increased Intestinal Epithelial Cell Proliferation and Tumor Development

Increased dietary fat consumption is associated with colon cancer development. The exact mechanism by which fat induces colon cancer is not clear, however, increased bile acid excretion in response to high-fat diet may promote colon carcinogenesis. The farnesoid X receptor (FXR) is a member of the n...

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Hlavní autoři: Maran, Rengasamy R.M., Thomas, Ann, Roth, Megan, Sheng, Zhonghua, Esterly, Noriko, Pinson, David, Gao, Xin, Zhang, Yawei, Ganapathy, Vadivel, Gonzalez, Frank J., Guo, Grace L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Pharmacology and Experimental Therapeutics 2009
Témata:
Gastrointestinal, Hepatic, Pulmonary, and Renal
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2682273/
https://ncbi.nlm.nih.gov/pubmed/18981289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.108.145409
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