Farnesoid X Receptor Deficiency in Mice Leads to Increased Intestinal Epithelial Cell Proliferation and Tumor Development

Increased dietary fat consumption is associated with colon cancer development. The exact mechanism by which fat induces colon cancer is not clear, however, increased bile acid excretion in response to high-fat diet may promote colon carcinogenesis. The farnesoid X receptor (FXR) is a member of the n...

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Detalhes bibliográficos
Main Authors: Maran, Rengasamy R.M., Thomas, Ann, Roth, Megan, Sheng, Zhonghua, Esterly, Noriko, Pinson, David, Gao, Xin, Zhang, Yawei, Ganapathy, Vadivel, Gonzalez, Frank J., Guo, Grace L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Pharmacology and Experimental Therapeutics 2009
Assuntos:
Gastrointestinal, Hepatic, Pulmonary, and Renal
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2682273/
https://ncbi.nlm.nih.gov/pubmed/18981289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.108.145409
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