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UV as an amplifier rather than inducer of NF-κB activity

Inflammatory activation of NF-κB involves the stimulus-induced degradation of the NF-κB-bound inhibitor, IκB, via the IκB kinase (IKK). In response to UV irradiation, however, the mechanism and function of NF-κB activation remain unclear. Using a combined biochemical, genetic, and computational mode...

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Main Authors: O’Dea, Ellen L., Kearns, Jeffrey D., Hoffmann, Alexander
格式: Artigo
語言:Inglês
出版: 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2682114/
https://ncbi.nlm.nih.gov/pubmed/18538661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.03.017
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