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H2AX Is Required for Cell Cycle Arrest via the p53/p21 Pathway

Phosphorylation of H2AX (γH2AX) is an early sign of DNA damage induced by replication stalling. However, the role of H2AX in the repair of this type of DNA damage is still unclear. In this study, we used an inactivated adeno-associated virus (AAV) to induce a stalled replication fork signal and inve...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Fragkos, Michalis, Jurvansuu, Jaana, Beard, Peter
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2009
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2682023/
https://ncbi.nlm.nih.gov/pubmed/19273588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01830-08
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