Effect of Preexisting Immunity on an Adenovirus Vaccine Vector: In Vitro Neutralization Assays Fail To Predict Inhibition by Antiviral Antibody In Vivo

A major obstacle to the use of adenovirus vectors derived from common human serotypes, such as human adenovirus 5 (AdHu5), is the high prevalence of virus-neutralizing antibodies in the human population. We previously constructed a variant of chimpanzee adenovirus 68 (AdC68) that maintained the fund...

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Hlavní autoři: Pichla-Gollon, Susan L., Lin, Shih-Wen, Hensley, Scott E., Lasaro, Marcio O., Herkenhoff-Haut, Larissa, Drinker, Mark, Tatsis, Nia, Gao, Guang-Ping, Wilson, James M., Ertl, Hildegund C. J., Bergelson, Jeffrey M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2009
Témata:
Gene Delivery
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2681979/
https://ncbi.nlm.nih.gov/pubmed/19279092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00405-09
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