Mutations in the Nonstructural Protein 3A Confer Resistance to the Novel Enterovirus Replication Inhibitor TTP-8307

A novel compound, TTP-8307, was identified as a potent inhibitor of the replication of several rhino- and enteroviruses. TTP-8307 inhibits viral RNA synthesis in a dose-dependent manner, without affecting polyprotein synthesis and/or processing. Drug-resistant variants of coxsackievirus B3 were all...

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Detalhes bibliográficos
Main Authors: De Palma, Armando M., Thibaut, Hendrik Jan, van der Linden, Lonneke, Lanke, Kjerstin, Heggermont, Ward, Ireland, Stephen, Andrews, Robert, Arimilli, Murty, Al-Tel, Taleb H., De Clercq, Erik, van Kuppeveld, Frank, Neyts, Johan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2681499/
https://ncbi.nlm.nih.gov/pubmed/19237651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00934-08
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