The Thiazolobenzimidazole TBZE-029 Inhibits Enterovirus Replication by Targeting a Short Region Immediately Downstream from Motif C in the Nonstructural Protein 2C

TBZE-029 {1-(2,6-difluorophenyl)-6-trifluoromethyl-1H,3H-thiazolo[3,4-a]benzimidazole} is a novel selective inhibitor of the replication of several enteroviruses. We show that TBZE-029 exerts its antiviral activity through inhibition of viral RNA replication, without affecting polyprotein processing...

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Detalhes bibliográficos
Main Authors: De Palma, Armando M., Heggermont, Ward, Lanke, Kjerstin, Coutard, Bruno, Bergmann, Mirko, Monforte, Anna-Maria, Canard, Bruno, De Clercq, Erik, Chimirri, Alba, Pürstinger, Gerhard, Rohayem, Jacques, van Kuppeveld, Frank, Neyts, Johan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2346740/
https://ncbi.nlm.nih.gov/pubmed/18337578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01338-07
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