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Activation of farnesoid X receptor prevents atherosclerotic lesion formation in LDLR(−/−) and apoE(−/−) mice
The role of farnesoid X receptor (FXR) in the development of atherosclerosis has been unclear. Here, LDL receptor (LDLR(−/−)) or apolipoprotein E (apoE(−/−)) female or male mice were fed a Western diet and treated with a potent synthetic FXR agonist, WAY-362450. Activation of FXR blocked diet-induce...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Biochemistry and Molecular Biology
2009
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2681391/ https://ncbi.nlm.nih.gov/pubmed/19174369 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M800619-JLR200 |
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