Marinobufagenin induces increases in procollagen expression in a process involving protein kinase C and Fli-1: implications for uremic cardiomyopathy

The cardiotonic steroid marinobufagenin (MBG) has been implicated in the pathogenesis of experimental uremic cardiomyopathy, which is characterized by progressive cardiac fibrosis. We examined whether the transcription factor Friend leukemia integration-1 (Fli-1) might be involved in this process. F...

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Hlavní autoři: Elkareh, Jihad, Periyasamy, Sankaridrug M., Shidyak, Amjad, Vetteth, Sandeep, Schroeder, Jeremy, Raju, Vanamala, Hariri, Imad M., El-Okdi, Nasser, Gupta, Shalini, Fedorova, Larisa, Liu, Jiang, Fedorova, Olga V., Kahaleh, M. Bashar, Xie, Zijian, Malhotra, Deepak, Watson, Dennis K., Bagrov, Alexei Y., Shapiro, Joseph I.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2681369/
https://ncbi.nlm.nih.gov/pubmed/19261738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.90710.2008
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