The cardiotonic steroid hormone marinobufagenin induces renal fibrosis: implication of epithelial-to-mesenchymal transition

We recently demonstrated that the cardiotonic steroid marinobufagenin (MBG) induced fibrosis in rat hearts through direct stimulation of collagen I secretion by cardiac fibroblasts. This stimulation was also responsible for the cardiac fibrosis seen in experimental renal failure. In this study, the...

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Main Authors: Fedorova, Larisa V., Raju, Vanamala, El-Okdi, Nasser, Shidyak, Amjad, Kennedy, David J., Vetteth, Sandeep, Giovannucci, David R., Bagrov, Alexei Y., Fedorova, Olga V., Shapiro, Joseph I., Malhotra, Deepak
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2009
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973402/
https://ncbi.nlm.nih.gov/pubmed/19176701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.90605.2008
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