Blunting of AICAR-induced human skeletal muscle glucose uptake in type 2 diabetes is dependent on age rather than diabetic status

We demonstrated previously that, in healthy young men, 5-aminoimidazole-4-carboxamide 1-β-d-ribofuranoside (AICAR) stimulates human muscle 2-deoxyglucose (2DG) uptake without detectable activation of muscle AMP-activated protein kinase (AMPK) but with extracellular-regulated kinase 1/2 (ERK1/2) acti...

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Main Authors: Babraj, John Andree, Mustard, Kristy, Sutherland, Calum, Towler, Mhari C., Chen, Shaui, Smith, Kenneth, Green, Kevin, Leese, Graham, Hardie, David Grahame, Rennie, Michael J., Cuthbertson, Daniel James
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2009
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2681307/
https://ncbi.nlm.nih.gov/pubmed/19190259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.90811.2008
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