Loading...

Reverse genetic analysis of Caenorhabditis elegans presenilins reveals redundant but unequal roles for sel-12 and hop-1 in Notch-pathway signaling

Mutations in the human presenilin genes PS1 and PS2 cause early-onset Alzheimer’s disease. Studies in Caenorhabditis elegans and in mice indicate that one function of presenilin genes is to facilitate Notch-pathway signaling. Notably, mutations in the C. elegans presenilin gene sel-12 reduce signali...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Westlund, Bethany, Parry, Dianne, Clover, Ralph, Basson, Michael, Johnson, Carl D.
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 1999
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC26813/
https://ncbi.nlm.nih.gov/pubmed/10051671
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!