Leptin Inhibits Glycogen Synthase Kinase-3β to Prevent Tau Phosphorylation in Neuronal Cells

We have previously demonstrated that Leptin reduces extracellular amyloid β (Aβ) protein both in vitro and in vivo, and intracellular tau phosphorylation in vitro. Further, we have shown that these effects are dependent on activation of AMP-activated protein kinase (AMPK) in vitro. Herein, we invest...

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Détails bibliographiques
Auteurs principaux: Greco, Steven J., Sarkar, Sraboni, Casadesus, Gemma, Zhu, Xiongwei, Smith, Mark A., Ashford, J. Wesson, Johnston, Jane M., Tezapsidis, Nikolaos
Format: Artigo
Langue:Inglês
Publié: 2009
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2681253/
https://ncbi.nlm.nih.gov/pubmed/19429119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2009.03.066
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