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Hematopoietic stem cells do not depend on N-cadherin to regulate their maintenance

According to the “osteoblastic niche” model, hematopoietic stem cells (HSCs) are maintained by N-cadherin-mediated homophilic adhesion to osteoblasts at the bone marrow endosteum. In contrast to this model, we cannot detect N-cadherin expression by HSCs and most HSCs do not localize to the endosteal...

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Detalhes bibliográficos
Main Authors: Kiel, Mark J., Acar, Melih, Radice, Glenn L., Morrison, Sean J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2681089/
https://ncbi.nlm.nih.gov/pubmed/19119091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2008.10.005
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