Diminished Telomeric 3′ Overhangs Are Associated with Telomere Dysfunction in Hoyeraal-Hreidarsson Syndrome

BACKGROUND: Eukaryotic chromosomes end with telomeres, which in most organisms are composed of tandem DNA repeats associated with telomeric proteins. These DNA repeats are synthesized by the enzyme telomerase, whose activity in most human tissues is tightly regulated, leading to gradual telomere sho...

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מידע ביבליוגרפי
Main Authors: Lamm, Noa, Ordan, Elly, Shponkin, Rotem, Richler, Carmelit, Aker, Memet, Tzfati, Yehuda
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2009
נושאים:
Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2680952/
https://ncbi.nlm.nih.gov/pubmed/19461895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005666
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