Diminished Telomeric 3′ Overhangs Are Associated with Telomere Dysfunction in Hoyeraal-Hreidarsson Syndrome

BACKGROUND: Eukaryotic chromosomes end with telomeres, which in most organisms are composed of tandem DNA repeats associated with telomeric proteins. These DNA repeats are synthesized by the enzyme telomerase, whose activity in most human tissues is tightly regulated, leading to gradual telomere sho...

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Bibliografiska uppgifter
Huvudupphovsmän: Lamm, Noa, Ordan, Elly, Shponkin, Rotem, Richler, Carmelit, Aker, Memet, Tzfati, Yehuda
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2009
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2680952/
https://ncbi.nlm.nih.gov/pubmed/19461895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005666
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