Regulation of PI(3)K/Akt signalling and cellular transformation by inositol polyphosphate 4-phosphatase-1

Akt is a crucial phosphoinositide 3-kinase (PI(3)K) effector that regulates cell proliferation and survival. PI(3)K-generated signals, PtdIns(3,4,5)P(3) and PtdIns(3,4)P(2), direct Akt plasma membrane engagement. Pathological Akt plasma membrane association promotes oncogenesis. PtdIns(3,4)P(2) is d...

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Hlavní autoři: Ivetac, Ivan, Gurung, Rajendra, Hakim, Sandra, Horan, Kristy A, Sheffield, David A, Binge, Lauren C, Majerus, Philip W, Tiganis, Tony, Mitchell, Christina A
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2009
Témata:
Scientific Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2680870/
https://ncbi.nlm.nih.gov/pubmed/19325558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2009.28
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