Functional Substitution by TAT-Utrophin in Dystrophin-Deficient Mice

BACKGROUND: The loss of dystrophin compromises muscle cell membrane stability and causes Duchenne muscular dystrophy and/or various forms of cardiomyopathy. Increased expression of the dystrophin homolog utrophin by gene delivery or pharmacologic up-regulation has been demonstrated to restore membra...

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Main Authors: Sonnemann, Kevin J., Heun-Johnson, Hanke, Turner, Amy J., Baltgalvis, Kristen A., Lowe, Dawn A., Ervasti, James M.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2009
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2680620/
https://ncbi.nlm.nih.gov/pubmed/19478831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.1000083
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