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Identification of an Endogenous Ligand Bound to a Native Orphan Nuclear Receptor

Orphan nuclear receptors have been instrumental in identifying novel signaling pathways and therapeutic targets. However, identification of ligands for these receptors has often been based on random compound screens or other biased approaches. As a result, it remains unclear in many cases if the rep...

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Главные авторы: Yuan, Xiaohui, Ta, Tuong Chi, Lin, Min, Evans, Jane R., Dong, Yinchen, Bolotin, Eugene, Sherman, Mark A., Forman, Barry M., Sladek, Frances M.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2009
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2680617/
https://ncbi.nlm.nih.gov/pubmed/19440305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005609
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