Identification of an Endogenous Ligand Bound to a Native Orphan Nuclear Receptor

Orphan nuclear receptors have been instrumental in identifying novel signaling pathways and therapeutic targets. However, identification of ligands for these receptors has often been based on random compound screens or other biased approaches. As a result, it remains unclear in many cases if the rep...

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Main Authors: Yuan, Xiaohui, Ta, Tuong Chi, Lin, Min, Evans, Jane R., Dong, Yinchen, Bolotin, Eugene, Sherman, Mark A., Forman, Barry M., Sladek, Frances M.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2009
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2680617/
https://ncbi.nlm.nih.gov/pubmed/19440305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005609
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