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Potent synthetic and endogenous ligands for the adopted orphan nuclear receptor Nurr1

Until recently, Nurr1 (NR4A2) was known as an orphan nuclear receptor without a canonical ligand-binding domain, featuring instead a narrow and tight cavity for small molecular ligands to bind. In-depth characterization of its ligand-binding pocket revealed that it is highly dynamic, with its struct...

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Détails bibliographiques
Publié dans:Exp Mol Med
Auteurs principaux: Jang, Yongwoo, Kim, Woori, Leblanc, Pierre, Kim, Chun-Hyung, Kim, Kwang-Soo
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2021
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8080818/
https://ncbi.nlm.nih.gov/pubmed/33479411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s12276-021-00555-5
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