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Potent synthetic and endogenous ligands for the adopted orphan nuclear receptor Nurr1
Until recently, Nurr1 (NR4A2) was known as an orphan nuclear receptor without a canonical ligand-binding domain, featuring instead a narrow and tight cavity for small molecular ligands to bind. In-depth characterization of its ligand-binding pocket revealed that it is highly dynamic, with its struct...
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| Publicado no: | Exp Mol Med |
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| Principais autores: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8080818/ https://ncbi.nlm.nih.gov/pubmed/33479411 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s12276-021-00555-5 |
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