An Integrative Genomic and Proteomic Analysis of PIK3CA, PTEN, and AKT Mutations in Breast Cancer

Phosphatidylinositol 3-kinase (PI3K)/AKT pathway aberrations are common in cancer. By applying mass spectroscopy–based sequencing and reverse-phase protein arrays to 547 human breast cancers and 41 cell lines, we determined the subtype specificity and signaling effects of PIK3CA, AKT, and PTEN mutat...

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Hlavní autoři: Stemke-Hale, Katherine, Gonzalez-Angulo, Ana Maria, Lluch, Ana, Neve, Richard M., Kuo, Wen-Lin, Davies, Michael, Carey, Mark, Hu, Zhi, Guan, Yinghui, Sahin, Aysegul, Symmans, W. Fraser, Pusztai, Lajos, Nolden, Laura K., Horlings, Hugo, Berns, Katrien, Hung, Mien-Chie, van de Vijver, Marc J., Valero, Vicente, Gray, Joe W., Bernards, René, Mills, Gordon B., Hennessy, Bryan T.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2680495/
https://ncbi.nlm.nih.gov/pubmed/18676830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-07-6854
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