The novel plant-derived agent silvestrol has B-cell selective activity in chronic lymphocytic leukemia and acute lymphoblastic leukemia in vitro and in vivo

Therapeutic options for advanced B-cell acute lymphoblastic leukemia (ALL) and chronic lymphocytic leukemia (CLL) are limited. Available treatments can also deplete T lymphocytes, leaving patients at risk of life-threatening infections. In the National Cancer Institute cell line screen, the structur...

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Detalhes bibliográficos
Main Authors: Lucas, David M., Edwards, Ryan B., Lozanski, Gerard, West, Derek A., Shin, Jungook D., Vargo, Melissa A., Davis, Melanie E., Rozewski, Darlene M., Johnson, Amy J., Su, Bao-Ning, Goettl, Virginia M., Heerema, Nyla A., Lin, Thomas S., Lehman, Amy, Zhang, Xiaoli, Jarjoura, David, Newman, David J., Byrd, John C., Kinghorn, A. Douglas, Grever, Michael R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2009
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2680369/
https://ncbi.nlm.nih.gov/pubmed/19190247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-09-175430
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