Autotaxin and lysophosphatidic acid stimulate intestinal cell motility by redistribution of the actin modifying protein villin to the developing lamellipodia

Autotaxin (ATX) is a potent tumor cell motogen that can produce lysophosphatidic acid (LPA) from lysophosphatidylcholine. LPA is a lipid mediator that has also been shown to modulate tumor cell invasion. Autotaxin mRNA is expressed at high levels in the intestine. Likewise, LPA(2) receptor levels ha...

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Bibliografische gegevens
Hoofdauteurs: Khurana, Seema, Tomar, Alok, George, Sudeep P., Wang, Yaohong, Siddiqui, Mohammad Rizwan, Guo, Huazhang, Tigyi, Gabor, Mathew, Sijo
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2007
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2680351/
https://ncbi.nlm.nih.gov/pubmed/18054784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexcr.2007.10.028
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