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Mechanism of IS200/IS605 Family DNA Transposases: Activation and Transposon-Directed Target Site Selection
The smallest known DNA transposases are those from the IS200/IS605 family. Here we show how the interplay of protein and DNA activates TnpA, the Helicobacter pylori IS608 transposase, for catalysis. First, transposon end binding causes a conformational change that aligns catalytically important prot...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2008
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2680152/ https://ncbi.nlm.nih.gov/pubmed/18243097 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2007.12.029 |
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