Mechanism of IS200/IS605 Family DNA Transposases: Activation and Transposon-Directed Target Site Selection

The smallest known DNA transposases are those from the IS200/IS605 family. Here we show how the interplay of protein and DNA activates TnpA, the Helicobacter pylori IS608 transposase, for catalysis. First, transposon end binding causes a conformational change that aligns catalytically important prot...

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Bibliographic Details
Main Authors: Barabas, Orsolya, Ronning, Donald R., Guynet, Catherine, Hickman, Alison Burgess, Ton-Hoang, Bao, Chandler, Michael, Dyda, Fred
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2680152/
https://ncbi.nlm.nih.gov/pubmed/18243097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2007.12.029
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