Evidence that chronic alcohol exposure promotes intestinal oxidative stress, intestinal hyperpermeability and endotoxemia prior to development of alcoholic steatohepatitis in rats

BACKGROUND/AIMS: Not all alcoholics develop liver disease (ALD). Thus, excessive ethanol consumption is necessary, but not sufficient, to induce alcoholic steatohepatitis (ASH) & ALD. Since endotoxemia is present in patients with ALD, it has been proposed that gut-derived, circulating endotoxin...

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Hlavní autoři: Keshavarzian, Ali, Farhadi, Ashkan, Forsyth, Christopher B., Rangan, Jayanthi, Jakate, Shriram, Shaikh, Maliha, Banan, Ali, Fields, Jeremy Z.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2680133/
https://ncbi.nlm.nih.gov/pubmed/19155080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2008.10.028
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