Nitric oxide mediated intestinal injury is required for alcohol-induced gut leakiness and liver damage

BACKGROUND: Alcoholic liver disease (ALD) requires endotoxemia and is commonly associated with intestinal barrier leakiness. Using monolayers of intestinal epithelial cells as an in vitro barrier model, we showed that ethanol-induced intestinal barrier disruption is mediated by iNOS (inducible nitri...

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Main Authors: Tang, Yueming, Forsyth, Christopher B., Farhadi, Ashkan, Rangan, Jayanthi, Jakate, Shriram, Shaikh, Maliha, Banan, Ali, Fields, Jeremy Z., Keshavarzian, Ali
Format: Artigo
Sprog:Inglês
Udgivet: 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2950098/
https://ncbi.nlm.nih.gov/pubmed/19389191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1530-0277.2009.00946.x
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