Insights into substrate stabilization from snapshots of the peptidyl transferase center of the intact 70S ribosome

Protein synthesis is catalyzed in the peptidyl transferase center (PTC), located in the large (50S) subunit of the ribosome. No high-resolution structure of the intact ribosome has contained a complete active site including both A- and P-site tRNAs. Additionally, though structures of the 50S subunit...

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Bibliographic Details
Main Authors: Voorhees, Rebecca M., Weixlbaumer, Albert, Loakes, David, Kelley, Ann C., Ramakrishnan, V.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2679717/
https://ncbi.nlm.nih.gov/pubmed/19363482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1577
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