Biochemical Properties of Purified Human Retinol Dehydrogenase 12 (RDH12): Catalytic Efficiency toward Retinoids and C(9) Aldehydes and Effects of Cellular Retinol-Binding Protein Type I (CRBPI) and Cellular Retinaldehyde-Binding Protein (CRALBP) on the Oxidation and Reduction of Retinoids

Retinol dehydrogenase 12 (RDH12) is a novel member of the short-chain dehydrogenase/reductase superfamily of proteins that was recently linked to Leber’s congenital amaurosis 3 (LCA). We report the first biochemical characterization of purified human RDH12 and analysis of its expression in human tis...

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Hauptverfasser: Belyaeva, Olga V., Korkina, Olga V., Stetsenko, Anton V., Kim, Tom, Nelson, Peter S., Kedishvili, Natalia Y.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2005
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2679700/
https://ncbi.nlm.nih.gov/pubmed/15865448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi050226k
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