Direct Impairment of Vascular Function by Diesel Exhaust Particulate through Reduced Bioavailability of Endothelium-Derived Nitric Oxide Induced by Superoxide Free Radicals

BACKGROUND: Diesel exhaust particulate (DEP) is a key arbiter of the adverse cardiovascular effects of air pollution. OBJECTIVES: We assessed the in vitro effects of DEP on vascular function, nitric oxide (NO) availability, and the generation of oxygen-centered free radicals. METHODS: We assessed th...

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Main Authors: Miller, Mark R., Borthwick, Stephen J., Shaw, Catherine A., McLean, Steven G., McClure, Daniel, Mills, Nicholas L., Duffin, Rodger, Donaldson, Ken, Megson, Ian L., Hadoke, Patrick W.F., Newby, David E.
Formato: Artigo
Idioma:Inglês
Publicado: National Institute of Environmental Health Sciences 2009
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Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2679606/
https://ncbi.nlm.nih.gov/pubmed/19440501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/ehp.0800235
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