Structure-Activity–Dependent Regulation of Cell Communication by Perfluorinated Fatty Acids using in Vivo and in Vitro Model Systems

BACKGROUND: Perfluoroalkanoates, [e.g., perfluorooctanoate (PFOA)], are known peroxisome proliferators that induce hepatomegaly and hepatocarcinogenesis in rodents, and are classic non-genotoxic carcinogens that inhibit in vitro gap-junctional intercellular communication (GJIC). This inhibition of G...

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Main Authors: Upham, Brad L., Park, Joon-Suk, Babica, Pavel, Sovadinova, Iva, Rummel, Alisa M., Trosko, James E., Hirose, Akihiko, Hasegawa, Ryuichi, Kanno, Jun, Sai, Kimie
Formato: Artigo
Idioma:Inglês
Publicado: National Institute of Environmental Health Sciences 2009
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Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2679597/
https://ncbi.nlm.nih.gov/pubmed/19440492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/ehp.11728
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