Phosphatidylinositol 3-Kinase-dependent Activation of Mammalian Protein Kinase B/Akt in Saccharomyces cerevisiae, an in Vivo Model for the Functional Study of Akt Mutations

In animal cells, Akt (also called protein kinase B) is activated by stimuli that elevate the level of phosphatidylinositol 3,4,5-trisphosphate and is a major effector for eliciting responses that support cell growth and survival. We have shown previously that co-expression of Akt1 in budding yeast (...

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Bibliographic Details
Main Authors: Rodríguez-Escudero, Isabel, Andrés-Pons, Amparo, Pulido, Rafael, Molina, María, Cid, Víctor J.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Mechanisms of Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2679437/
https://ncbi.nlm.nih.gov/pubmed/19307184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807867200
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