STAT3 inhibits the degradation of HIF-1α by pVHL-mediated ubiquitination

Hypoxia-inducible factor 1α (HIF-1α) is rapidly degraded by the ubiquitin-proteasome pathway under normoxic conditions. Ubiquitination of HIF-1α is mediated by interaction with von Hippel-Lindau tumor suppressor protein (pVHL). In our previous report, we found that hypoxia-induced active signal tran...

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Autori principali: Jung, Joo Eun, Kim, Hong Sook, Lee, Chang Seok, Shin, Yong-Jae, Kim, Yong-Nyun, Kang, Gyeong-Hoon, Kim, Tae-You, Juhnn, Yong-Sung, Kim, Sung-Joon, Park, Jong-Wan, Ye, Sang-Kyu, Chung, Myung-Hee
Natura: Artigo
Lingua:Inglês
Pubblicazione: Korean Society of Medical Biochemistry and Molecular Biology 2008
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2679355/
https://ncbi.nlm.nih.gov/pubmed/18985005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3858/emm.2008.40.5.479
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