Effects of ketoconazole and carbamazepine on lapatinib pharmacokinetics in healthy subjects

AIMS: To characterize the impact of potent CYP3A4 inhibition and induction on lapatinib pharmacokinetics. METHODS: Two studies were conducted in healthy subjects. One study examined the effect of ketoconazole 200 mg b.i.d. for 7 days on a single 100-mg dose of lapatinib in 22 healthy subjects. The o...

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Bibliographic Details
Main Authors:	Smith, Deborah A, Koch, Kevin M, Arya, Nikita, Bowen, Carolyn J, Herendeen, Jill M, Beelen, Andrew
Format:	Artigo
Language:	Inglês
Published:	Blackwell Science Inc 2009
Subjects:	Drug Interactions
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2679105/ https://ncbi.nlm.nih.gov/pubmed/19371315 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2009.03370.x
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Effects of ketoconazole and carbamazepine on lapatinib pharmacokinetics in healthy subjects

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