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Approaches to Handling Data When a Phase II Trial Deviates from the Pre-specified Simon's Two-Stage Design

Simon's ‘optimal’ and ‘minimax’ two-stage designs are common methods for conducting phase IIA studies investigating new cancer therapies. However, these designs are rather rigid in their settings because of the pre-specified rejection rules and fixed sample sizes at each stage. In practice, we...

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Bibliografiske detaljer
Main Authors: Wu, Yujun, Shih, Weichung J.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2678911/
https://ncbi.nlm.nih.gov/pubmed/18800338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.3426
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