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Bmi1 lineage tracing identifies a self-renewing pancreatic acinar cell subpopulation capable of maintaining pancreatic organ homeostasis

A central question in stem cell biology is whether organ homeostasis is maintained in adult organs through undifferentiated stem cells or self-duplication of specialized cell populations. To address this issue in the exocrine pancreas we analyzed the Bmi1-labeled cell lineage of pancreatic acinar ce...

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Autores principales: Sangiorgi, Eugenio, Capecchi, Mario R.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2009
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2678421/
https://ncbi.nlm.nih.gov/pubmed/19372370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0902508106
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