Lysosome-Associated Membrane Proteins (LAMP) Maintain Pancreatic Acinar Cell Homeostasis: LAMP-2–Deficient Mice Develop Pancreatitis

BACKGROUND & AIMS: The pathogenic mechanism of pancreatitis is poorly understood. Recent evidence implicates defective autophagy in pancreatitis responses; however, the pathways mediating impaired autophagy in pancreas remain largely unknown. Here, we investigate the role of lysosome associated...

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Bibliographic Details
Published in:Cell Mol Gastroenterol Hepatol
Main Authors: Mareninova, Olga A., Sendler, Matthias, Malla, Sudarshan Ravi, Yakubov, Iskandar, French, Samuel W., Tokhtaeva, Elmira, Vagin, Olga, Oorschot, Viola, Lüllmann-Rauch, Renate, Blanz, Judith, Dawson, David, Klumperman, Judith, Lerch, Markus M., Mayerle, Julia, Gukovsky, Ilya, Gukovskaya, Anna S.
Format: Artigo
Language:Inglês
Published: Elsevier 2015
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673685/
https://ncbi.nlm.nih.gov/pubmed/26693174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2015.07.006
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