Mucosal Immunization of Cynomolgus Macaques with the VSVΔG/ZEBOVGP Vaccine Stimulates Strong Ebola GP-Specific Immune Responses

BACKGROUND: Zaire ebolavirus (ZEBOV) produces a lethal viral hemorrhagic fever in humans and non-human primates. METHODOLOGY/PRINCIPAL FINDINGS: We demonstrate that the VSVΔG/ZEBOVGP vaccine given 28 days pre-challenge either intranasally (IN), orally (OR), or intramuscularly (IM) protects non-human...

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Autores principales: Qiu, Xiangguo, Fernando, Lisa, Alimonti, Judie B., Melito, P. Leno, Feldmann, Friedericke, Dick, Daryl, Ströher, Ute, Feldmann, Heinz, Jones, Steven M.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2678264/
https://ncbi.nlm.nih.gov/pubmed/19440245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005547
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