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IL-23, not IL-12, Directs Autoimmunity to the Goodpasture Antigen
The autoantigen in Goodpasture disease is the noncollagenous domain of α3 type IV collagen [α3(IV)NC1]. We previously demonstrated that IL-12p40(−/−) mice are protected from experimental autoimmune anti–glomerular basement membrane (anti-GBM) glomerulonephritis, seemingly defining a role for IL-12 i...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Nephrology
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2678043/ https://ncbi.nlm.nih.gov/pubmed/19357249 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2008080891 |
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