The HLA-DRB1*15:01–Restricted Goodpasture’s T Cell Epitope Induces GN

Human anti-glomerular basement membrane (GBM) disease strongly associates with HLA-DRB1*15:01. The target autoantigen in this disease is the noncollagenous domain of the α3 chain of type IV collagen, α3(IV)NC1, but critical early T cell epitopes presented by this human MHC class II molecule are unkn...

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Detalhes bibliográficos
Main Authors: Ooi, Joshua D., Chang, Janet, O’Sullivan, Kim M., Pedchenko, Vadim, Hudson, Billy G., Vandenbark, Arthur A., Fugger, Lars, Holdsworth, Stephen R., Kitching, A. Richard
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2013
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3582203/
https://ncbi.nlm.nih.gov/pubmed/23411782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2012070705
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