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Novel inhibitors of Anthrax edema factor
Several pathogenic bacteria produce adenylyl cyclase toxins, such as the edema factor (EF) of Bacillus anthracis. These disturb cellular metabolism by catalyzing production of excessive amounts of the regulatory molecule cAMP. Here, a structure-based method, where a 3D- pharmacophore that fit the ac...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2678011/ https://ncbi.nlm.nih.gov/pubmed/18620864 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2008.06.036 |
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